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了解FoxP3、CCL22和CCR4 mRNA在宫颈癌组织中的表达情况,探究各因子的免疫调节作用及对肿瘤的影响。方法:采用实时定量聚合酶链反应检测30例宫颈癌癌灶、癌旁和20例正常宫颈组织中,FoxP3、CCL22和CCR4 mRNA表达水平。
CCR4与肿瘤的关系及其临床意义
胸腺和活化调节的趋化因子(TARC) 巨噬细胞衍生的趋化因子(MDC 肿瘤
2010/3/18
CCR4是CC趋化因子受体(CC chemokine receptor, CCR)家族中的一员,主要表达于多种淋巴细胞。其高亲和力配体为胸腺和活化调节的趋化因子 (thymus and activation regulated chemokine,TARC/CCL17)及巨噬细胞衍生的趋化因子(macrophagederived chemokine,MDC/CCL22/STCP1)。CCR4主...
Increased Number of CCR4-positive Cells in the Duodenum of Ovalbumin-induced Food Allergy Model NC/jic Mice and Antiallergic Activity of Fructooligosaccharides
antiallergic activity CCR4- and CCR5-positive cells food allergy fructooligosaccharides prebiotic food
2007/6/18
The number of CCR4-positive cells increased significantly in Group 2 as compared with Group 1 and tended to decrease in Group 3 as compared with Group 2. Relatively few CCR5-positive cells were observ...